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It should be noted that older adults are particularly prone to developing delirium as the result of either using or withdrawing from a drug (Schuckit, 1990). This is due to age-related changes in the body's ability to metabolize and distribute a drug. As a result, the development of delirium is more frequent during conditions such as alcohol withdrawal (Miller, 1991).
Assessment includes a careful review of the medical history, interviews with the client and knowledgeable family members, and screening for cognitive impairment. Because clients may not be able to accurately describe their symptoms, family members can be queried about medical issues (e.g., medication changes) as well as the recency of behavioral and cognitive impairments. In terms of screening questions, the Mini-Mental Status Exam (MMSE; Folstein, Folstein, & McHugh, 1975) is the most widely used screening instrument for differentiating organic and functional mental disorders (Tombaugh & McIntyre, 1992). Although it only takes 5-10 minutes to administer, MMSE assesses orientation, memory, attention, concentration, language, and visual-motor ability. Finally, particular mental status questions can be quite useful. These include asking the client to repeat a series of digits forward (attention), recall three words after 5 minutes (short-term memory), and draw a clock (visual-motor; Lindesay el. al, 1990; Mungas, 1991). Attention and degree of consciousness can be further assessed by asking the client to indicate each time the letter A is said in a series of 15 or so random letters.
In terms of differential diagnosis, delirium is most often confused with dementia or an acute psychosis (APA, 1994; Conn, 1991). Differentiating delirium and dementia is particularly difficult because about a quarter of those who present with delirium have a preexisting dementia (Conn, 1991; Lindesay et al., 1990). Dementia caused by Alzheimer's disease (AD) can be distinguished by the chronicity of symptoms over months to years, the lack of sudden worsening of symptoms, less diurnal variation, and better performance on attention tasks (APA, 1994; Conn, 1991). Dementia due to small strokes--termed multi-infarct dementia in DSM-III-R and vascular dementia in DSM-IV shows more circumscribed impairment (e.g., memory, aphasia), and alertness and attention are typically intact (Cummings & Benson, 1.983). In differentiating psychotic disorders from delirium, the former are more likely to be characterized by a prior psychiatric history, systematized (versus fleeting) delusions, and less pervasive cognitive impairment (Conn, 1991).
In the remaining 20% of older persons with dementia, the cause is another physical disorder such as a metabolic disturbance (e.g., hypothyroidism, kidney disease), a vitamin deficiency (especially the B vitamins), Parkinson's disease, excess fluid in the brain (hydrocephalus), alcoholism, or prescription drugs. The most commonly used medications that can cause dementia include psychotropics (especially lithium, tricyclic antidepressants, benzodiazepines, and phenothiazines), antihypertensives (e.g., methyldopa, clonidine, diuretics), anticancer medications, and antibiotics (Cummings & Benson, 1983; Hinrichsen, 1990; Salzman & Nevis-Owen, 1992). These medications can impair cognitive abilities by either toxicity effects or alterations in other bodily systems that effect mental functioning. For example, elderly people are particularly sensitive to the side-effects of drugs like phenothiazines (e.g., prolixin) and trycyclic antidepressants because they can disrupt cholinergic synaptic functioning in the brain and cause memory as well as other cognitive impairments (Cummings & Benson, 1983; Salzman & Nevis-Owen, 1992). While AD and cerebrovascular disease cause irreversible cognitive impairment, dementia caused by many of the other medical disorders can be reversed if treatment is initiated promptly (Brock & Simpson, 1990; Read, 1991).
The pattern of symptoms can help to differentiate the different types of dementia as well as the degree of progression. In AD, memory disturbance is the hallmark feature. During the first phase of the disorder, short-term memory is impaired followed by problems with long-term memory (Cummings & Benson, 1983). The individual may forget things like turning off the oven or completing a task if interrupted. Expressive aphasia may begin to manifest itself in the form of word finding problems. The individual may get lost or become disoriented in unfamiliar surroundings. In the second phase of AD, further cognitive impairment becomes evident in the form of agnosia and apraxia. Language expression and comprehension worsens to the point that coherent conversation becomes difficult. Personality is frequently characterized by indifference and apathy (Benson & Cummings, 1986). Skills needed to live independently (e.g., cooking, cleaning, managing money) become impaired as well as some basic living skills such as grooming and bathing. In the last phase of AD, cognitive abilities worsen to the point that higher intellectual abilities and self-care skills disappear altogether (Cummings & Benson, 1983).
Vascular dementia, the second most common type of dementia, has a number of characteristic features that can help to differentiate it from AD (Benson & Cummings, 1986; Hinrichsen, 1990; Read, 1991). In vascular dementia, the individual loses some cognitive ability as a result of a small stroke or series of strokes. Although cognitive loss in AD is slow and progressive (over months to years), impairment occurs more abruptly in vascular dementia (from hours to days). A family member might report, for example, that her father suddenly has more word finding problems or is more forgetful. Other aspects of behavior such as the ability to use a computer may be unimpaired. A few months later another abrupt decline in cognitive functioning may occur with deterioration showing this stepwise decline over time. Another difference is that vascular dementia frequently presents with soft neurological signs such as slight weakness in one hand, difficulty pronouncing words, or difficulty swallowing (APA, 1994). It should be considered whenever the client either has had a history of a stroke or has risk factors such as hypertension, smoking, atherosclerosis, or diabetes (Benson & Cummings, 1986).
Metabolic disorders and disorders like Parkinson's disease and Huntington's disease can cause somewhat different patterns of symptoms in dementia. First, these disorders do not typically produce aphasia in contrast to either vascular dementia or AD (Cummings & Benson, 1983). Second, memory problems in these disorders are not as pervasive as in AD. Third, the clinical picture tends to be dominated by symptoms such as depressed affect, slowed thinking, and movement disturbances such as facial grimacing, tremors, and rigidity (Read, 1991).
The diagnostic picture is complicated by the fact that depression, psychosis, or delirium can be a secondary feature in most types of dementia (APA, 1994; Lindesay et al., 1990). For example, about a third of those who develop AD or vascular dementia will also have a secondary depression or psychosis that seems to be organic in nature (Jeste & Krull, 1991; Read, 1991; Rovner; 1992). In terms of differential diagnosis, secondary psychosis tends to be characterized by nonelaborated delusions (e.g., "Someone is stealing my things") or simple hallucinations (Jeste & Krull, 1991). Systematized delusions (e.g., elaborate plots), ideas of reference, and thought insertion are more characteristic of a functional psychosis like schizophrenia.
A number of assessment instruments have been found to be particularly useful in the diagnostic process (Fields, 1991; Hinkle, 1990; Mungas, 1991). First, benign forgetfulness can be differentiated from early dementia by scores of 25 and above on the MMSE, good performance on in-office memory tasks, and a pattern of forgetfulness that is characterized by forgetting aspects of an event versus the event itself (Addonizio & Shamoian, 1986). Those who have dementia, however, will score below 20 on the MMSE and show impairment in mental status areas such as memory, abstraction, and figure drawing (Mungas, 1991). Furthermore, depending on how far the dementia has progressed, there also may be deficits in self-care skills such as shopping or cooking. In this regard, a number of scales are available that assess the client's functioning across a range of living skills (Blessed, Tomilson, & Roth, 1968; Fillenbaum, 1985; Pfeiffer, Johnson, & Chiofolo, 1981).
The major diagnostic categories to consider with depression include major depressive disorder, dysthymia, adjustment disorder with depressed mood, and bereavement. In addition, physical factors such as disease or medications can cause an organic depression (Allen & Blazer, 1991).
Bereavement.Bereavement is the normal reaction to the death of a loved one and may include a number of depressive symptoms (APA, 1994). But what are signs that bereavement has become complicated by a more serious condition, like major depression? A depressive disorder may be present if the clinical picture is dominated by symptoms such as worthlessness, suicidal preoccupation, excessive guilt, hallucinatory experiences, and psychomotor retardation (APA, 1994; Brock & Simpson, 1990). Too, there may be a great deal of impairment in social functioning (e.g., client avoids people altogether) or occupational endeavors (e.g., client is unable to work). In assessing the severity of the reaction, the counselor should consider the time since the loss, the length of impairment, and cultural differences that might moderate the mode of grieving. In DSM-IV (APA, 1994) a major depressive disorder can be diagnosed if numerous depressive symptoms persist beyond 2 months after the loss.
Adjustment disorder.Adjustment disorder with depressed mood entails a maladaptive reaction to a stressor that manifests itself in either moderate symptoms or moderate impairment in social, inter-personal, or occupational functioning (APA, 1994). According to DSM-IV (APA, 1994), symptoms should only persist for 6 months after the termination of the stressor or its consequences. For example, retirement might trigger depressed mood, a sense of worthlessness, and loss of energy that persists for 5 months. There is some evidence that older adults react to stress with depression, whereas younger adults are more likely to become aroused and anxious (Allen & Blazer, 1991; Gintner, Hollandsworth, & Intrieri, 1986). The clinician should rule out a major depressive disorder and dysthymia when examining symptom severity and duration.
Dysthymia.In DSM-IV (APA, 1994) dysthymia is characterized by the presence of depressed mood plus two other depressive symptoms that persist for at least 2 years. In elderly people, it is not uncommon for dysthymia to be triggered by chronic illness, functional loss, social isolation, or a complicated bereavement reaction. The principal differential diagnosis is with a major depressive disorder that can mimic dysthymia by peaking early over a 2-year period and slowly dissipating over time.
In older adults, however, chronic symptoms such as fatigue, low energy, and appetite disturbance can also be due to chronic illnesses, medications, or alcohol use (Allen & Blazer, 1991; Small, 1991). Chronic illnesses that may produce dysthymia-like symptoms include endocrine disorders (e.g., hypothyroidism, diabetes), infections (e.g., Epstein-Barr), strokes, and neurological disorders like Parkinson's disease (Brock & Simpson, 1990; Small, 1991). Organically induced depressive symptoms can also be caused by prolonged use of anti-hypertensives (especially reserpine, methyldopa, and beta-blockers), hormones (e.g., estrogen), antiparkinsonian drugs (e.g., levodopa), and analgesics (Allen & Blazer, 1991; Brock & Simpson, 1990; Small, 1991).
Major depressive disorder.The diagnosis of a major depressive disorder requires the presence of five depression symptoms for at least 2 weeks (APA, 1994). Of these, one of the symptoms must be depressed mood or loss of interest or pleasure in most activities. Elderly clients, however, often have a masked presentation: Their affect may be neutral and complaints about changes in mood may be absent (McCullough, 1991; Small, 1991). The clinical picture may be dominated by apathy, withdrawal, vague somatic complaints, and loss of interest (Katz et al., 1988).
Differential diagnosis entails ruling out organic conditions, bipolar disorder, dementia, and a functional psychosis such as schizophrenia. All the medical disorders and medications that can mimic dysthymia are also capable of producing symptoms severe enough to mimic a major depressive disorder (Brock & Simpson, 1990). An organic mood disorder of this severity, however, may have some important differences: Instead of a client's mood seeming neutral, severe organic depression is frequently associated with a flat affect and a monotone voice (Conn, 1991). These features are especially characteristic of stroke victims, of whom 25% develop organic depression (Conn, 1991; Small, 1991). In terms of differential diagnosis, there is some evidence that those with a major depressive disorder versus a medical condition are more likely to report worthlessness and have a history of mood disorder (Allen & Blazer, 1991; Brock & Simpson, 1990).
Late-onset schizophrenia may also mimic a major depressive disorder. The delusions in late-onset schizophrenia tend to be more systematized than in a psychotic depression, and there tend to be fewer depression-like symptoms than are found in a major depressive disorder (Katz et al., 1988).
In older adults especially, a major depressive disorder can be accompanied by cognitive impairments in areas such as memory, attention, concentration, and processing speed (Addonizio & Shamoian, 1986). A number of differences between depression and dementia have been identified that can be useful in making a differential diagnosis. First, the clients with depression are more likely to complain about memory problems and highlight their disabilities (Addonizio & Shamoian, 1986; Small, 1991). Second, depressed clients will generally show more variation of their cognitive performance over 1 month's time, especially in comparison to an individual with AD (Allen & Blazer, 1991). Third, onset of cognitive problems tends to be more sudden (e.g., over weeks) than is seen in AD. Fourth, symptoms such as aphasia, agnosia, and apraxia are rare if only depression is present (Cummings & Benson, 1983). Finally, the depressed client's performance on tests or questions is more likely to show a pattern of errors due to omissions (e.g., not trying, quitting), rather than commission of gross mistakes (Addonizio & Shamoian, 1986; Brock & Simpson, 1990).
A number of depression inventories have been validated with older adults (Allen & Blazer, 1991). Among the most commonly used are the Beck Depression Inventory (Beck, Ward, Mendelson, Mock, & Erbaugh, 1961) and the Geriatric Depression Scale (Yesavage et at., 1983). There is some evidence that indicates that clinicians should use these tests cautiously because clients may underreport their symptoms or have cognitive impairment (Koenig et al., 1992). Inventories also may be less sensitive in identifying depression in elderly African Americans (Koenig et al., 1992).
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